Response
During infectious disease emergencies such as COVID-19, APPRISE coordinates effective research to inform Australia’s response.
Example response activities:
- develop diagnostic tests for new and emerging infections
- ensure appropriate diagnostic tests can be used in remote locations
- begin clinical trials for new treatments and vaccines
- facilitate effective sharing and analysis of research data, working closely with Australian and jurisdictional governments
- collect and store samples from people affected by an infectious disease to understand clinical severity and treatment responses (biobanking)
- clearly communicate research findings to our diverse stakeholders
From 2017 until 2022, APPRISE projects were funded by the National Health and Medical Research Council to prepare Australia for infectious disease emergencies
Projects
- A COVID-19 decision aid to support adult and child vaccine uptake in multicultural communities
- Establishing a national biobank for COVID-19
- First Nations-led projects funded for COVID-19 research
- National and targeted sero-surveys of population immunity to SARS-COV2 to inform clinical and public health responses
- AuStralian COVID Trial (ASCOT)
- The interaction between influenza and SARS-CoV-2 in nursing homes
- REMAP-CAP for COVID 19
- First Nations Community Panels on COVID-19
- The ethics of Australia’s quarantine choices: Health security, COVID-19 and Christmas Island
- Understanding host response of severe viral pneumonitis
- Self-isolation and quarantine experiences during the COVID-19 pandemic: A qualitative study
- First Nations Disaster Management Plans for COVID-19
- Understanding stakeholder beliefs, attitudes and responses to COVID-19 infection prevention and control (IPC): a multimodal qualitative study
- CRISPER: COVID-19 Real-time Information System for Preparedness and Epidemic Response
- NHMRC extends APPRISE funding for critical COVID-19 projects
- Frequently Asked Questions – ‘First Few X’ (FFX) project to enhance the public health response to COVID-19 in Australia
- ‘First Few X’ (FFX) research project to enhance the public health response to COVID-19 in Australia
- Fast-tracked new COVID-19 projects meet areas of urgent need
- Community perspectives on distributing an initially limited supply of vaccines in the event of an influenza pandemic
- Influenza sero-surveillance at the animal-human interface: a feasibility study in high-risk groups
- Sampling, shipping and serology: a proof of concept study of influenza immunity
- Short PeRiod IncideNce sTudy of Severe Acute Respiratory Infection (SPRINT-SARI): research preparedness for pandemics
- Sentinel Travellers and Research Preparedness Platform for Emerging Infectious Disease (SETREP-ID)
- ASEAN-Australia Health Security Fellowship Program
- Evaluating video-reflexive methods to improve infection prevention and use of personal protective equipment in Australian hospitals
- Human parechovirus 3 (HPeV3) recombinant strain diversity and severe disease association in Australian outbreaks
Publications
- Long COVID in Australia: achieving equitable access to supportive health care
- Understanding routine (non-outbreak) respiratory protective equipment behaviour of hospital workers in different clinical settings – lessons for the future post COVID-19
- WHO keeps covid-19 a public health emergency of international concern
- A modelling approach to estimate the transmissibility of SARS-CoV-2 during periods of high, low, and zero case incidence
- Aged care residents — and everybody else — would benefit from better control of COVID-19 transmission
- Evaluation of the Australian first few X household transmission project for COVID-19
- “You can’t replace that feeling of connection to culture and country”: Aboriginal and Torres Strait Islander Parents’ experiences of the COVID-19 pandemic
- Nafamostat mesylate for treatment of COVID-19 in hospitalised patients: A structured, narrative review
- Anticoagulation strategies in non–critically ill patients with Covid-19
- Key features of a trauma-informed public health emergency approach: A rapid review
- A culturally responsive trauma-informed public health emergency framework for Aboriginal and Torres Strait Islander Communities in Australia, developed during COVID-19
- Convergence of surveillance blind spots with antimicrobial resistance hotspots
- Key lessons from the COVID-19 public health response in Australia
- Contact tracing indicators for COVID-19: Rapid scoping review and conceptual framework
- An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients
- Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- ISARIC-COVID-19 dataset: A prospective, standardized, global dataset of patients hospitalized with COVID-19
- Effectiveness evaluation of digital contact tracing for COVID-19 in New South Wales, Australia
- Serological testing of blood donors to characterise the impact of COVID-19 in Melbourne, Australia, 2020
- The value of open-source clinical science in pandemic response: lessons from ISARIC
- Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Exploring healthcare workers’ perspectives of video feedback for training in the use of powered air purifying respirators (PAPR) at the onset of the COVID-19 pandemic
- ‘Like building a plane and flying it all in one go’: an interview study of infection prevention and control in Australian general practice during the first 2 years of the SARS-CoV-2 pandemic
- Learnings from the Australian first few X household transmission project for COVID-19
- Transmission of SARS-CoV-2 in standardised first few X cases and household transmission investigations: A systematic review and meta-analysis
- Engage, understand, listen and act: evaluation of Community Panels to privilege First Nations voices in pandemic planning and response in Australia
- HPeV3 diversity, recombination and clinical impact across 7-years: an Australian story
- Virology and immune dynamics reveal high household transmission of ancestral SARS-CoV-2 strain
- Relative effectiveness of COVID-19 vaccination with 3 compared to 2 doses against SARS-CoV-2 B.1.1.529 (Omicron) among an Australian population with low prior rates of SARS-CoV-2 infection [preprint]
- People in intensive care with COVID-19: demographic and clinical features during the first, second, and third pandemic waves in Australia
- Paradoxes of pandemic infection control: Proximity, pace and care within and beyond SARS-CoV-2
- Using systems thinking to better understand risks and protective factors for urban Indigenous peoples during COVID-19
- Experiences of risk in Australian hotel quarantine: a qualitative study
- Effect of antiplatelet therapy on survival and organ support-free days in critically ill patients with COVID-19: A randomized clinical trial
- Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol
- Transmission of SARS-CoV-2 in standardised First Few X cases and household transmission investigations: a systematic review and meta-analysis [preprint]
- Priorities in Biobanking Research: A Report on the 2021 ISBER Round Table
- What is needed to sustain improvements in hospital practices post-COVID-19? A qualitative study of interprofessional dissonance in hospital infection prevention and control
- The ongoing value of first few X studies for COVID-19 in the Western Pacific Region
- Rapid assessment of the risk of SARS-CoV-2 importation: case study and lessons learned
- COVID-19 in low-tolerance border quarantine systems: Impact of the Delta variant of SARS-CoV-2
- The Burden of the Beast. Countering conspiracies and misinformation within Indigenous communities in Australia
- Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2-specific antibodies in Australia after the first epidemic wave in 2020: A national survey
- Uncertainty and agency in COVID-19 hotel quarantine in Australia
- A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2
- Experiences of the SARS-CoV-2 pandemic amongst Australian Healthcare workers: From stressors to protective factors
- Glucocorticoid dose in COVID-19: Lessons for clinical trials during a pandemic
- “One minute it’s an airborne virus, then it’s a droplet virus, and then it’s like nobody really knows…”: Experiences of pandemic PPE amongst Australian healthcare workers
- Understanding how Victoria, Australia gained control of its second COVID-19 wave
- Effect of convalescent plasma on organ support–free days in critically ill patients with COVID-19. A randomized clinical trial
- Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials
- Prospective characterisation of SARS-CoV-2 infections among children presenting to tertiary paediatric hospitals across Australia in 2020: a national cohort study
- Development of the COVID-19 Real-Time Information System for Preparedness and Epidemic Response (CRISPER), Australia
- Doherty Modelling–Final report to National Cabinet 5th November 2021
- Respiratory virus detection during the COVID-19 pandemic in Queensland, Australia
- ATAGI 2021 annual statement on immunisation Last updated: 19 September 2021
- Longitudinal evaluation of laboratory-based serological assays for SARS-CoV-2 antibody detection
- Policy considerations for mandatory COVID-19 vaccination from the Collaboration on Social Science in Immunisation
- Modelling testing and response strategies for COVID-19 outbreaks in remote Australian Aboriginal communities
- Essential Emergency and Critical Care: a consensus among global clinical experts
- Entanglements of affect, space, and evidence in pandemic healthcare: An analysis of Australian healthcare workers’ experiences of COVID-19
- Decision-making for pandemics: an ethics framework
- Optimal allocation of PCR tests to minimise disease transmission through contact tracing and quarantine
- Doherty Modelling Interim Report to National Cabinet 17th September 2021
- Doherty Modelling Report Revised 10th August 2021
- Therapeutic anticoagulation with heparin in critically ill patients with Covid-19
- Therapeutic anticoagulation with heparin in noncritically ill patients with Covid-19
- Whole of population-based cohort study of recovery time from COVID-19 in New South Wales Australia
- Evaluation of 6 commercial SARS-CoV-2 serology assays detecting different antibodies for clinical testing and serosurveillance
- Doherty Modelling Report for National Cabinet 30 July 2021
- Leading with local solutions to keep Yarrabah safe: a grounded theory study of an Aboriginal community-controlled health organisation’s response to COVID-19
- Australia needs a prioritised national research strategy for clinical trials in a pandemic: lessons learned from COVID-19
- The impact of the COVID‐19 pandemic on routine vaccinations in Victoria
- Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance
- An increased ratio of SARS-CoV-2 positive to negative sense genomic and subgenomic RNAs within routine diagnostic upper respiratory tract swabs may be a marker of virion shedding [preprint]
- Temporal differences in culturable severe acute respiratory coronavirus virus 2 (SARS-CoV-2) from the respiratory and gastrointestinal tracts in a patient with moderate coronavirus disease 2019 (COVID-19)
- Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
- COVID‐19 Real‐time Information System for Preparedness and Epidemic Response (CRISPER)
- Multi-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: A validation and implementation study
- Interleukin-6 receptor antagonists in critically ill patients with Covid-19
- Hospital outcomes after a COVID-19 diagnosis from January to May 2020 in New South Wales Australia
- Outcomes for patients with COVID‐19 admitted to Australian intensive care units during the first four months of the pandemic
- How should we conduct pandemic vaccination?
- Constructing an ethical framework for priority allocation of pandemic vaccines
- How do data bolster pandemic preparedness and response? How do we improve data and systems to be better prepared?
- Education and training in infection prevention and control: Exploring support for national standards
- Where has all the influenza gone? The impact of COVID-19 on the circulation of influenza and other respiratory viruses, Australia, March to September 2020
- Maintaining strong foundations and building resilience: planning Australia’s path through the COVID-19 pandemic
- COVID-19 public health measures and respiratory syncytial virus
- SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication
- Estimating temporal variation in transmission of COVID-19 and adherence to social distancing measures in Australia
- Coronavirus disease model to inform transmission reducing measures and health system preparedness, Australia
- Early analysis of the Australian COVID-19 epidemic
- Changes in public preferences for technologically enhanced surveillance following the COVID-19 pandemic: a discrete choice experiment
- Seroprevalence of SARS-CoV-2-specific antibodies in Sydney, Australia following the first epidemic wave in 2020
- Ending COVID-19: progress and gaps in research—highlights of the July 2020 GloPID-R COVID-19 Research Synergies Meetings
- Leveraging the advances in HIV for COVID-19
- COVID‐19 in a Sydney nursing home: a case study and lessons learnt
- Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19. The REMAP-CAP COVID-19 corticosteroid domain randomized clinical trial
- Medical interns’ reflections on their training in use of personal protective equipment
- Geospatial epidemiology of Staphylococcus aureus in a tropical setting: an enabling digital surveillance platform
- Attributable length of stay, mortality risk and costs of bacterial healthcare-associated infections in Australia: a retrospective case-cohort study
- Tracking the COVID-19 pandemic in Australia using genomics
- Building an ethics framework for COVID-19 resource allocation: The How and the Why
- An ethics framework for making resource allocation decisions within clinical care: Responding to COVID-19
- Transmission of SARS-CoV-2 in Australian educational settings: a prospective cohort study
- Outcomes reported for Australian First Nation populations for the influenza A(H1N1) 2009 pandemic and lessons for future infectious disease emergencies: a systematic review
- RDA COVID-19 Working Group recommendations and guidelines on data sharing
- Prioritising access to pandemic influenza vaccine: a review of the ethics literature
- Webinar: Bioethics and COVID-19
- The challenges of establishing adequate capacity for SARS‐CoV‐2 testing
- Isolation and rapid sharing of the 2019 novel coronavirus (SARS ‐CoV‐2) from the first patient diagnosed with COVID ‐19 in Australia
- First Nations people leading the way in COVID-19 pandemic planning, response and management
- Rapid research report – The most promising therapeutics for COVID-19
- Trajectories of hospital infection control: Using non-representational theory to understand and improve infection prevention and control
- Key ethical concepts and their application to COVID-19 research
- Estimating the case detection rate and temporal variation in transmission of COVID-19 in Australia
- Modelling the impact of COVID-19 in Australia to inform transmission reducing measures and health system preparedness [pre-print]
- Early analysis of the Australian COVID-19 epidemic [preprint]
- Assessing the risk of spread of COVID-19 to the Asia Pacific region [preprint]
- SARS, MERS and COVID-19—new threats; old lessons
- Living with COVID-19: Planning policy for the next stage
- An ethics framework for making resource allocation decisions within clinical care: Responding to COVID-19
- Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
- Breadth of concomitant immune responses underpinning viral clearance and patient recovery in a non-severe case of COVID-19
- Enablers of, and barriers to, optimal glove and mask use for routine care in the emergency department: an ethnographic study of Australian clinicians
- Presenteeism among health care workers with laboratory-confirmed influenza infection: A retrospective cohort study in Queensland, Australia
- Respiratory illness in a piggery associated with the first identified outbreak of swine influenza in Australia: Assessing the risk to human health and zoonotic potential
- Advancing Planetary Health in Australia: focus on emerging infections and antimicrobial resistance
- Towards effective outbreak detection: a qualitative study to identify factors affecting nurses’ early warning surveillance practice in Solomon Islands
- Priority needs for conducting pandemic-relevant clinical research with children in Europe: A consensus study with pediatric clinician-researchers
- Communicable disease surveillance ethics in the age of big data and new technology
- Clinician perceptions of respiratory infection risk; a rationale for research into mask use in routine practice
- Influenza epidemiology, vaccine coverage and vaccine effectiveness in children admitted to sentinel Australian hospitals in 2017: Results from the PAEDS-FluCAN Collaboration
- Clinical research networks and assessing pandemic severity
- Presentation: A mixed methods study of the risk-taking behaviour of clinical staff towards routine use of protective masks for infectious diseases
- Presentation: Talking with patients: Improving clinician-patient communication around healthcare-associated infections using video-reflexive methods
- Presentation: Keeping our hospitals safe from exotic infections
- Planning for and responding to pandemic influenza emergencies: it’s time to listen to, prioritize and privilege Aboriginal perspectives
- Characterising seasonal influenza epidemiology using primary care surveillance data
- To follow a rule? On frontline clinicians’ understandings and embodiments of hospital-acquired infection prevention and control rules
- Parechovirus: an important emerging infection in young infants
- Stakeholder Consultation Report – Australian Partnership for Preparedness Research on Infectious Disease Emergencies: NHMRC Centre for Research Excellence
- Is Australia prepared for the next pandemic?
- Developing research priorities for Australia’s response to infectious disease emergencies