Response
During an infectious disease emergency, APPRISE will coordinate effective research to inform Australia’s response.
Example response activities:
- develop diagnostic tests for new and emerging infections
- ensure appropriate diagnostic tests can be used in remote locations
- begin clinical trials for new treatments and vaccines
- facilitate effective sharing and analysis of research data, working closely with Australian and jurisdictional governments
- collect and store samples from people affected by an infectious disease to understand clinical severity and treatment responses (biobanking)
- clearly communicate research findings to our diverse stakeholders.
APPRISE COVID-19 updates:
Projects
- A COVID-19 decision aid to support adult and child vaccine uptake in multicultural communities
- Establishing a national biobank for COVID-19
- First Nations-led projects funded for COVID-19 research
- National and targeted sero-surveys of population immunity to SARS-COV2 to inform clinical and public health responses
- AuStralian COVID Trial (ASCOT)
- The interaction between influenza and SARS-CoV-2 in nursing homes
- REMAP-CAP for COVID 19
- First Nations Community Panels on COVID-19
- The ethics of Australia’s quarantine choices: Health security, COVID-19 and Christmas Island
- Understanding host response of severe viral pneumonitis
- Self-isolation and quarantine experiences during the COVID-19 pandemic: A qualitative study
- First Nations Disaster Management Plans for COVID-19
- Understanding stakeholder beliefs, attitudes and responses to COVID-19 infection prevention and control (IPC): a multimodal qualitative study
- CRISPER: COVID-19 Real-time Information System for Preparedness and Epidemic Response
- NHMRC extends APPRISE funding for critical COVID-19 projects
- Frequently Asked Questions – ‘First Few X’ (FFX) project to enhance the public health response to COVID-19 in Australia
- ‘First Few X’ (FFX) research project to enhance the public health response to COVID-19 in Australia
- Fast-tracked new COVID-19 projects meet areas of urgent need
- Community perspectives on distributing an initially limited supply of vaccines in the event of an influenza pandemic
- Influenza sero-surveillance at the animal-human interface: a feasibility study in high-risk groups
- Sampling, shipping and serology: a proof of concept study of influenza immunity
- Short PeRiod IncideNce sTudy of Severe Acute Respiratory Infection (SPRINT-SARI): research preparedness for pandemics
- Sentinel Travellers and Research Preparedness Platform for Emerging Infectious Disease (SETREP-ID)
- ASEAN-Australia Health Security Fellowship Program
- Evaluating video-reflexive methods to improve infection prevention and use of personal protective equipment in Australian hospitals
- Human parechovirus 3 (HPeV3) recombinant strain diversity and severe disease association in Australian outbreaks
Publications
- WHO keeps covid-19 a public health emergency of international concern
- A modelling approach to estimate the transmissibility of SARS-CoV-2 during periods of high, low, and zero case incidence
- Aged care residents — and everybody else — would benefit from better control of COVID-19 transmission
- Evaluation of the Australian first few X household transmission project for COVID-19
- “You can’t replace that feeling of connection to culture and country”: Aboriginal and Torres Strait Islander Parents’ experiences of the COVID-19 pandemic
- Nafamostat mesylate for treatment of COVID-19 in hospitalised patients: A structured, narrative review
- Anticoagulation strategies in non–critically ill patients with Covid-19
- Key features of a trauma-informed public health emergency approach: A rapid review
- A culturally responsive trauma-informed public health emergency framework for Aboriginal and Torres Strait Islander Communities in Australia, developed during COVID-19
- Convergence of surveillance blind spots with antimicrobial resistance hotspots
- Key lessons from the COVID-19 public health response in Australia
- Contact tracing indicators for COVID-19: Rapid scoping review and conceptual framework
- An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients
- Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- ISARIC-COVID-19 dataset: A prospective, standardized, global dataset of patients hospitalized with COVID-19
- Effectiveness evaluation of digital contact tracing for COVID-19 in New South Wales, Australia
- Serological testing of blood donors to characterise the impact of COVID-19 in Melbourne, Australia, 2020
- The value of open-source clinical science in pandemic response: lessons from ISARIC
- Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Exploring healthcare workers’ perspectives of video feedback for training in the use of powered air purifying respirators (PAPR) at the onset of the COVID-19 pandemic
- ‘Like building a plane and flying it all in one go’: an interview study of infection prevention and control in Australian general practice during the first 2 years of the SARS-CoV-2 pandemic
- Learnings from the Australian first few X household transmission project for COVID-19
- Transmission of SARS-CoV-2 in standardised first few X cases and household transmission investigations: A systematic review and meta-analysis
- Engage, understand, listen and act: evaluation of Community Panels to privilege First Nations voices in pandemic planning and response in Australia
- HPeV3 diversity, recombination and clinical impact across 7-years: an Australian story
- Virology and immune dynamics reveal high household transmission of ancestral SARS-CoV-2 strain
- Relative effectiveness of COVID-19 vaccination with 3 compared to 2 doses against SARS-CoV-2 B.1.1.529 (Omicron) among an Australian population with low prior rates of SARS-CoV-2 infection [preprint]
- People in intensive care with COVID-19: demographic and clinical features during the first, second, and third pandemic waves in Australia
- Paradoxes of pandemic infection control: Proximity, pace and care within and beyond SARS-CoV-2
- Using systems thinking to better understand risks and protective factors for urban Indigenous peoples during COVID-19
- Experiences of risk in Australian hotel quarantine: a qualitative study
- Effect of antiplatelet therapy on survival and organ support-free days in critically ill patients with COVID-19: A randomized clinical trial
- Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol
- Transmission of SARS-CoV-2 in standardised First Few X cases and household transmission investigations: a systematic review and meta-analysis [preprint]
- Priorities in Biobanking Research: A Report on the 2021 ISBER Round Table
- What is needed to sustain improvements in hospital practices post-COVID-19? A qualitative study of interprofessional dissonance in hospital infection prevention and control
- The ongoing value of first few X studies for COVID-19 in the Western Pacific Region
- Rapid assessment of the risk of SARS-CoV-2 importation: case study and lessons learned
- COVID-19 in low-tolerance border quarantine systems: Impact of the Delta variant of SARS-CoV-2
- The Burden of the Beast. Countering conspiracies and misinformation within Indigenous communities in Australia
- Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2-specific antibodies in Australia after the first epidemic wave in 2020: A national survey
- Uncertainty and agency in COVID-19 hotel quarantine in Australia
- A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2
- Experiences of the SARS-CoV-2 pandemic amongst Australian Healthcare workers: From stressors to protective factors
- Glucocorticoid dose in COVID-19: Lessons for clinical trials during a pandemic
- “One minute it’s an airborne virus, then it’s a droplet virus, and then it’s like nobody really knows…”: Experiences of pandemic PPE amongst Australian healthcare workers
- Understanding how Victoria, Australia gained control of its second COVID-19 wave
- Effect of convalescent plasma on organ support–free days in critically ill patients with COVID-19. A randomized clinical trial
- Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials
- Prospective characterisation of SARS-CoV-2 infections among children presenting to tertiary paediatric hospitals across Australia in 2020: a national cohort study
- Development of the COVID-19 Real-Time Information System for Preparedness and Epidemic Response (CRISPER), Australia
- Doherty Modelling–Final report to National Cabinet 5th November 2021
- Respiratory virus detection during the COVID-19 pandemic in Queensland, Australia
- ATAGI 2021 annual statement on immunisation Last updated: 19 September 2021
- Longitudinal evaluation of laboratory-based serological assays for SARS-CoV-2 antibody detection
- Policy considerations for mandatory COVID-19 vaccination from the Collaboration on Social Science in Immunisation
- Modelling testing and response strategies for COVID-19 outbreaks in remote Australian Aboriginal communities
- Essential Emergency and Critical Care: a consensus among global clinical experts
- Entanglements of affect, space, and evidence in pandemic healthcare: An analysis of Australian healthcare workers’ experiences of COVID-19
- Decision-making for pandemics: an ethics framework
- Optimal allocation of PCR tests to minimise disease transmission through contact tracing and quarantine
- Doherty Modelling Interim Report to National Cabinet 17th September 2021
- Doherty Modelling Report Revised 10th August 2021
- Therapeutic anticoagulation with heparin in critically ill patients with Covid-19
- Therapeutic anticoagulation with heparin in noncritically ill patients with Covid-19
- Whole of population-based cohort study of recovery time from COVID-19 in New South Wales Australia
- Evaluation of 6 commercial SARS-CoV-2 serology assays detecting different antibodies for clinical testing and serosurveillance
- Doherty Modelling Report for National Cabinet 30 July 2021
- Leading with local solutions to keep Yarrabah safe: a grounded theory study of an Aboriginal community-controlled health organisation’s response to COVID-19
- Australia needs a prioritised national research strategy for clinical trials in a pandemic: lessons learned from COVID-19
- The impact of the COVID‐19 pandemic on routine vaccinations in Victoria
- Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance
- An increased ratio of SARS-CoV-2 positive to negative sense genomic and subgenomic RNAs within routine diagnostic upper respiratory tract swabs may be a marker of virion shedding [preprint]
- Temporal differences in culturable severe acute respiratory coronavirus virus 2 (SARS-CoV-2) from the respiratory and gastrointestinal tracts in a patient with moderate coronavirus disease 2019 (COVID-19)
- Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
- COVID‐19 Real‐time Information System for Preparedness and Epidemic Response (CRISPER)
- Multi-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: A validation and implementation study
- Interleukin-6 receptor antagonists in critically ill patients with Covid-19
- Hospital outcomes after a COVID-19 diagnosis from January to May 2020 in New South Wales Australia
- Outcomes for patients with COVID‐19 admitted to Australian intensive care units during the first four months of the pandemic
- How should we conduct pandemic vaccination?
- Constructing an ethical framework for priority allocation of pandemic vaccines
- How do data bolster pandemic preparedness and response? How do we improve data and systems to be better prepared?
- Education and training in infection prevention and control: Exploring support for national standards
- Where has all the influenza gone? The impact of COVID-19 on the circulation of influenza and other respiratory viruses, Australia, March to September 2020
- Maintaining strong foundations and building resilience: planning Australia’s path through the COVID-19 pandemic
- COVID-19 public health measures and respiratory syncytial virus
- SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication
- Estimating temporal variation in transmission of COVID-19 and adherence to social distancing measures in Australia
- Coronavirus disease model to inform transmission reducing measures and health system preparedness, Australia
- Early analysis of the Australian COVID-19 epidemic
- Changes in public preferences for technologically enhanced surveillance following the COVID-19 pandemic: a discrete choice experiment
- Seroprevalence of SARS-CoV-2-specific antibodies in Sydney, Australia following the first epidemic wave in 2020
- Ending COVID-19: progress and gaps in research—highlights of the July 2020 GloPID-R COVID-19 Research Synergies Meetings
- Leveraging the advances in HIV for COVID-19
- COVID‐19 in a Sydney nursing home: a case study and lessons learnt
- Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19. The REMAP-CAP COVID-19 corticosteroid domain randomized clinical trial
- Medical interns’ reflections on their training in use of personal protective equipment
- Geospatial epidemiology of Staphylococcus aureus in a tropical setting: an enabling digital surveillance platform
- Attributable length of stay, mortality risk and costs of bacterial healthcare-associated infections in Australia: a retrospective case-cohort study
- Tracking the COVID-19 pandemic in Australia using genomics
- Building an ethics framework for COVID-19 resource allocation: The How and the Why
- An ethics framework for making resource allocation decisions within clinical care: Responding to COVID-19
- Transmission of SARS-CoV-2 in Australian educational settings: a prospective cohort study
- Outcomes reported for Australian First Nation populations for the influenza A(H1N1) 2009 pandemic and lessons for future infectious disease emergencies: a systematic review
- RDA COVID-19 Working Group recommendations and guidelines on data sharing
- Prioritising access to pandemic influenza vaccine: a review of the ethics literature
- Webinar: Bioethics and COVID-19
- The challenges of establishing adequate capacity for SARS‐CoV‐2 testing
- Isolation and rapid sharing of the 2019 novel coronavirus (SARS ‐CoV‐2) from the first patient diagnosed with COVID ‐19 in Australia
- First Nations people leading the way in COVID-19 pandemic planning, response and management
- Rapid research report – The most promising therapeutics for COVID-19
- Trajectories of hospital infection control: Using non-representational theory to understand and improve infection prevention and control
- Key ethical concepts and their application to COVID-19 research
- Estimating the case detection rate and temporal variation in transmission of COVID-19 in Australia
- Modelling the impact of COVID-19 in Australia to inform transmission reducing measures and health system preparedness [pre-print]
- Early analysis of the Australian COVID-19 epidemic [preprint]
- Assessing the risk of spread of COVID-19 to the Asia Pacific region [preprint]
- SARS, MERS and COVID-19—new threats; old lessons
- Living with COVID-19: Planning policy for the next stage
- An ethics framework for making resource allocation decisions within clinical care: Responding to COVID-19
- Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
- Breadth of concomitant immune responses underpinning viral clearance and patient recovery in a non-severe case of COVID-19
- Enablers of, and barriers to, optimal glove and mask use for routine care in the emergency department: an ethnographic study of Australian clinicians
- Presenteeism among health care workers with laboratory-confirmed influenza infection: A retrospective cohort study in Queensland, Australia
- Respiratory illness in a piggery associated with the first identified outbreak of swine influenza in Australia: Assessing the risk to human health and zoonotic potential
- Advancing Planetary Health in Australia: focus on emerging infections and antimicrobial resistance
- Towards effective outbreak detection: a qualitative study to identify factors affecting nurses’ early warning surveillance practice in Solomon Islands
- Priority needs for conducting pandemic-relevant clinical research with children in Europe: A consensus study with pediatric clinician-researchers
- Communicable disease surveillance ethics in the age of big data and new technology
- Clinician perceptions of respiratory infection risk; a rationale for research into mask use in routine practice
- Influenza epidemiology, vaccine coverage and vaccine effectiveness in children admitted to sentinel Australian hospitals in 2017: Results from the PAEDS-FluCAN Collaboration
- Clinical research networks and assessing pandemic severity
- Presentation: A mixed methods study of the risk-taking behaviour of clinical staff towards routine use of protective masks for infectious diseases
- Presentation: Talking with patients: Improving clinician-patient communication around healthcare-associated infections using video-reflexive methods
- Presentation: Keeping our hospitals safe from exotic infections
- Planning for and responding to pandemic influenza emergencies: it’s time to listen to, prioritize and privilege Aboriginal perspectives
- Characterising seasonal influenza epidemiology using primary care surveillance data
- To follow a rule? On frontline clinicians’ understandings and embodiments of hospital-acquired infection prevention and control rules
- Parechovirus: an important emerging infection in young infants
- Stakeholder Consultation Report – Australian Partnership for Preparedness Research on Infectious Disease Emergencies: NHMRC Centre for Research Excellence
- Is Australia prepared for the next pandemic?
- Developing research priorities for Australia’s response to infectious disease emergencies