Managing uncertainty in clinical trials: the role of adaptive trial designs

November 22, 2017

During infectious disease outbreaks, clinical trials to test treatments face a number of challenges including:

  • uncertainty about populations, interventions, comparators, effect size
  • uncertainty about differences in treatment effect
  • lead time, especially in fast moving outbreaks.

APPRISE researcher, Professor Steve Webb, presented a webinar discussing adaptive trial design and how trials can deal with uncertainty and be ready to use (but modifiable) prior to an epidemic or pandemic.

A video of his webinar is now available for viewing.

The webinar was hosted by Global Research Collaboration for Infectious Disease Preparedness (GloPID-R), an alliance to promote an effective research response within 48 hours of a significant infectious disease outbreak.