COVID-19 research links

APPRISE is supporting the international research effort to address the novel coronavirus disease (COVID-19) pandemic caused by the SARS-CoV-2 virus.

APPRISE updates:

We recognise the enormous amount of emerging material and aim to provide a reliable source of research links.

[Last updated 2 July 2020]

Global COVID-19 dashboards and tools

Global dashboard of coronavirus COVID-19 cases – from Johns Hopkins CSSE

WHO Coronavirus disease (COVID-19) dashboard – from the World Health Organization

COVID-19 Clinical Trials Interactive tool – from Infectious Diseases Data Observatory

WHO COVID-19 situation reports

Access daily reports.

First Nations and Indigenous COVID-19 research and information

Resources

  • United Nations – COVID-19 and Indigenous peoples. Includes information and resources. Access here.
  • National Indigenous Australians Agency – Coronavirus (COVID-19). Links include government and territory resources. Access here.
  • Australian Government. Coronavirus (COVID-19) resources for Aboriginal and Torres Strait Islander people and remote communities. Access here.
  • Australian Government, Management Plan for Aboriginal and Torres Strait Islander Populations. Access here.

Research papers, tools and comment

  • Crooks et al, First Nations people leading the way in COVID-19 pandemic planning, response and management, Medical Journal of Australia, published online 29 April 2020. Access here.
  • Dreise and Ali, COVID -19: A practical tool for preparedness and planning in an Indigenous primary care setting in Canada, Canadian Family Physician, published online 15 April 2020. Access here.
  • Soto and Hakim, Medical basis for increased susceptibility of COVID-19 among the Navajo and other Indigenous Tribes, Preprints, published online 14 April 2020. Access here.
  • Markham et al,  Indigenous Australians and the COVID-19 crisis: perspectives on public policy, Topical Issue no. 1/2020, Centre for Aboriginal Economic Policy Research, Australian National University, Canberra. Access here.
  • Bond and Singh, More than a refresh required for closing the gap of Indigenous health inequality, Medical Journal of Australia, published online 16 March 2020. Access here.

Editorials and comment

  • Halpern et al, Cognitive bias and public health policy during the COVID-19 pandemic, JAMA, published online 29 June 2020. Access here.
  • Taylor et al, Solidarity in the wake of COVID-19: reimagining the International Health Regulations, The Lancet, published online 19 June 2020. Access here.
  • Okell et al, Have deaths from COVID-19 in Europe plateaued due to herd immunity?, The Lancet, published online 11 June 2020. Access here.
  • Mullard, COVID-19 vaccine development pipeline gears up, Lancet, published online 6 June 2020. Access here.
  • Smith, The challenges of establishing adequate capacity for SARS‐CoV‐2 testing, Medical Journal Australia, published online 1 June 2020. Access here.
  • Editorial, Sustained suppression, Nature Biomedical Engineering, published online 13 May 2020. Access here.
  • Subbarao, SARS-CoV-2: A New Song Recalls an Old Melody, Cell Host & Microbe, published online 13 May 2020. Access here.
  • Gilbert, SARS, MERS and COVID-19—new threats; old lessons, International Journal of Epidemiology, posted online 3 May 2020. Access here.
  • Lipsitch et al, Antibody testing will enhance the power and accuracy of COVID-19-prevention trials, Nature Medicine, published online 27 April 2020. Access here.
  • Muhi et al, COVID-19 in Australian healthcare workers: Early experience of the Royal Melbourne Hospital emphasises the importance of community acquisition, MJA, published online 23 April 2020. Access here.
  • Plotkin and Caplan, Extraordinary diseases require extraordinary solutions, Vaccine, published online 20 April 2020. Access here.
  • Day, Covid-19: four fifths of cases are asymptomatic, China figures indicate, BMJ, published online 20 April 2020. Access here.
  • Editorial, Humanity tested, Nature Biomedical Engineering, published online 8 April 2020. Access here.
  • COVID-19 Clinical Research Coalition, Global coalition to accelerate COVID-19 clinical research in resource-limited settings, Lancet, published online 2 April 2020. Access here.
  • Peeples, News Feature: Avoiding pitfalls in the pursuit of a COVID-19 vaccine, PNAS, published online 30 March 2020. Access here.
  • Lurie et al, Developing Covid-19 vaccines at pandemic speed, NEJM, published online 30 March 2020. Access here.
  • Usher, WHO launches crowdfund for COVID-19 response, Lancet, published online 28 March 2020. Access here.
  • Cluver et al, Parenting in a time of COVID-19, Lancet, published online 25 March 2020. Access here.
  • Ritchie and Singanayagam, Immunosuppression for hyperinflammation in COVID-19: a double-edged sword? Lancet, published online 24 March 2020. Access here.
  • Meyer and Martin, How to reduce COVID-19 spread in long-term care facilities: Challenges and recommendations, Clinicians’ Biosecurity News, published online 23 March 2020. Access here.
  • Kinner et al, Prisons and custodial settings are part of a comprehensive response to COVID-19, Lancet Public Health, published online 17 March 2020. Access here.
  • Chen et al, Detection of Covid-19 in children in early January 2020 in Wuhan, China, NEJM, published online 12 March 2020. Access here.
  • Sharfstein et al, Diagnostic testing for the novel coronavirus, JAMA, published online 9 March 2020. Access here.
  • Fauci et al, Covid-19 — Navigating the uncharted, NEJM, published online 28 February 2020. Access here.
  • Bill Gates, Responding to Covid-19 — A once-in-a-century pandemic? NEJM, published online 28 February 2020. Access here.
  • The novel coronavirus outbreak: What we know and what we don’t, Cell, published online 19 February 2020. Access here.
  • Evidence of SARS-CoV-2 infection in returning travelers from Wuhan, China, NEJM, published online 18 February 2020. Access here.
  • Li and de Clercq, Therapeutic options for the 2019 novel coronavirus (2019-nCoV), Nature Reviews Drug Discovery, published online 10 February 2020. Access here.
  • Calling all coronavirus researchers: keep sharing, stay open, Nature, published online 4 Feb 2020. Access here.
  • Phelan et al, The Novel Coronavirus Originating in Wuhan, China – Challenges for Global Health Governance, JAMA, published online Jan 30, 2020. Access here.
  • Emerging understandings of 2019-nCoV, Lancet, published online Jan 24, 2020. Access here.
  • Wang et al, A novel coronavirus outbreak of global health concern, Lancet, published online Jan 24, 2020. Access here.
  • Heymann, Data sharing and outbreaks: best practice exemplified, Lancet, published online Jan 24, 2020. Access here.
  • Munster et al, A novel coronavirus emerging in China – Key questions for impact assessment, NEJM, published online Jan 24, 2020. Access here.

Planning and technical guidance

  • World Health Organization, 2019 Novel Coronavirus (2019‑nCoV): Strategic preparedness and response plan, draft as of 3 February 2020. Download PDF.
  • World Health Organization, Novel Coronavirus (2019-nCoV) technical guidance, online. Link here

Protocols

  • World Health Organization, Country & Technical Guidance – Coronavirus disease (COVID-19). Access here.
  • World Health Organization, Household transmission investigation protocol for 2019-novel coronavirus (2019-nCoV) infection, Version: 1.1, 25 January 2020. Access here.
  • World Health Organization, Protocol for assessment of potential risk factors for 2019-novel coronavirus (2019-nCoV) infection among health care workers in a health care setting, version 1.2, 3 February 2020. Access here.
  • World Health Organization, The First Few X (FFX) Cases and contact investigation protocol for 2019-novel coronavirus (2019-nCoV) infection, version 2, 10 February 2020. Access here.

Research papers (most recent first)

Basic epidemiological and clinical characterisation

  • Feldstein et al, Multisystem inflammatory syndrome in U.S. children and adolescents, NEJM, published online 29 June 2020. Access here.
  • Dufort et al, Multisystem inflammatory syndrome in children in New York State, NEJM, published online 29 June 2020. Access here.
  • Vizcarra et al, Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort, Lancet HIV, published online 28 May 2020. Access here.
  • Cummings et al, Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study, Lancet, published online 19 May 2020. Access here.
  • Verdoni et al, An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study, Lancet, published online 13 May 2020. Access here.
  • Salje et al, Estimating the burden of SARS-CoV-2 in France, Science, published online 13 May 2020. Access here.
  • Bi et al, Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study, Lancet Infectious Diseases, published online 27 April 2020. Access here.
  • Davis et al, Clinical trials for the prevention and treatment of coronavirus disease 2019 (COVID-19): The current state of play, Medical Journal of Australia [preprint version], pre-print published online 27 April 2020. Access here.
  • Arons et al, Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility, NEJM, published online 24 April 2020. Access here.
  • Yong et al, Connecting clusters of COVID-19: an epidemiological and serological investigation, Lancet Infectious Diseases, published online 21 April 2020. Access here.
  • Dondorp et al, Respiratory support in novel coronavirus disease (COVID-19) patients, with a focus on resource-limited settings, The American Journal of Tropical Medicine and Hygiene, published online 21 April 2020. Access here.
  • Grasselli et al, Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy, JAMA, published online 6 April 2020. Access here.
  • ISARIC – International Severe Acute Respiratory and Emerging Infections Consortium, Clinical data report, published online 2 April 2020. Access here.
  • Ferretti et al, Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing, Science, published online 31 March 2020. Access here.
  • Zeng et al, Neonatal early-onset Infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China, JAMA Pediatrics, published online 26 March 2020. Access here.
  • Thevarajan et al, Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19, Nature Medicine, published on 16 March 2020. Access here.
  • Li et al, Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2), Science, published on 16 March 2020. Access here.
  • Tang et al, Detection of novel coronavirus by RT-PCR in stool specimen from asymptomatic child, China, Emerging Infectious Diseases, published online 9 March 2020. Access here.
  • Zheng et al, COVID-19 and the cardiovascular system, Nature Reviews Cardiology, published online 5 March 2020. Access here.
  • Guan et al, Clinical characteristics of coronavirus disease 2019 in China, NEJM, published online 28 February 2020. Access here.
  • Lee et al, COVID-19 pneumonia: what has CT taught us?, Lancet Infectious Diseases, published online 24 February 2020. Access here.
  • Yang et al, Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study, Lancet Respiratory Medicine, published online 24 February 2020. Access here.
  • Wu and McGoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China – Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA, published online 24 February 2020. Access here.
  • China CDC, Vital surveillances: The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) — China, 2020, China CDC Weekly, published online February 17 2020. Access here.
  • Wang et al, Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China, JAMA, published online February 7, 2020. Access here.
  • Chen et al, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet, published online Jan 29 2020. Access here.
  • Backer et al, The incubation period of 2019-nCoV infections among travellers from Wuhan, China, medRxiv, posted Jan 28 2020. Access here.
  • Huang et al, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, published online Jan 24, 2020. Access here.
  • Zhu et al, A novel coronavirus from patients with pneumonia in China, 2019, NEJM, published online Jan 24 2020. Access here.
  • Wu et al, Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020, Eurosurveillance, published online Jan 23 2020. Access here.

Transmission

  • Chu et al, Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis, Lancet, published online 1 June 2020. Access here.
  • Jiang et al, Detection of severe acute respiratory syndrome coronavirus 2 RNA on surfaces in quarantine rooms.
  • Emerging Infectious Diseases, published online 18 May 2020. Access here.
  • Xiao et al, Infectious SARS-CoV-2 in feces of patient with severe COVID-19, Emerging Infectious Diseases, published online 18 May 2020. Access here.
  • Liu et al, Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)? PLoS Pathogens, published online 14 May 2020. Access here.
  • Liu et al, Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals, Nature, published online 27 April 2020. Access here.
  • Rothe et al, Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany, NEJM, published online 30 Jan 2020. Access here.
  • Li et al, Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia, NEJM, published online Jan 29 2020. Access here.
  • Phan et al, Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam, NEJM, published online Jan 28 2020. Access here.
  • Chan et al, A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster, Lancet, published online Jan 24 2020. Access here.

Disease and other modelling

  • Clark et al, Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study, Lancet Global Health, published online 15 June 2020. Access here.
  • Narayanan, A novel cohort analysis approach to determining the case fatality rate of COVID-19 and other infectious diseases, PLoS ONE, published online 15 June 2020. Access here.
  • Hsiang et al, The effect of large-scale anti-contagion policies on the COVID-19 pandemic, Nature, published online 8 June 2020. Access here.
  • Flaxman et al, Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe, Nature, published online 8 June 2020. Access here.
  • Gardiner et al, Royal Flying Doctor Service COVID-19 activity and surge modelling in Australia, Air Medical Journal, published online May 2020. Access here.
  • Peak et al, Individual quarantine versus active monitoring of contacts for the mitigation of COVID-19: a modelling study, Lancet Infectious Diseases, published online 20 May 2020. Access here.
  • Price et al, Early analysis of the Australian COVID-19 epidemic, medRxiv, posted online 30 April 2020. Access here.
  • Shearer et al, Assessing the risk of spread of COVID-19 to the Asia Pacific region, medRxiv, posted online 19 April 2020. Access here.
  • Price et al, Estimating the case detection rate and temporal variation in transmission of COVID-19 in Australia, Technical report posted online 14 April 2020. Access here.
  • Moss et al, Modelling the impact of COVID-19 in Australia to inform transmission reducing measures and health system preparedness, medRxiv, posted online 11 April 2020. Access here.
  • Fox et al, Modelling the impact of COVID-19 upon intensive care services in New South Wales, Medical Journal of Australia [preprint version], published online 30 March 2020. Access here.
  • Verity et al, Estimates of the severity of coronavirus disease 2019: a model-based analysis, Lancet Infectious Diseases, published online 30 March 2020. Access here.
  • Koo et al, Interventions to mitigate early spread of SARS-CoV-2 in Singapore: a modelling study, Lancet Infectious Diseases, published online 23 March 2020. Access here.
  • Lai et al, Assessing spread risk of Wuhan novel coronavirus within and beyond China, January-April 2020: a travel network-based modelling study, medRxiv, posted online 9 March 2020. Access here.
  • Wu et al, Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study, Lancet, published online 31 Jan 2020. Access here.
  • Leung and Wu, Real-time nowcast and forecast on the extent of the Wuhan CoV outbreak, domestic and international spread, Media Conference Jan 27 2020. Download PDF.
  • Imai et al, Report 3: Transmissibility of 2019-nCoV, published online Jan 25 2020. Download PDF
  • Chinazzi et al, Preliminary assessment of the international spreading risk associated with the 2019 novel coronavirus (2019-nCoV) outbreak in Wuhan City, Center for Inference & Dynamics of Infectious Diseases, published online Jan 17 2020. Download PDF.
  • Bogoch et al, Pneumonia of unknown etiology in Wuhan, China: Potential for international spread via commercial air travel, Journal of Travel Medicine, published online Jan 14 2020. Access here.

Virology. immunity and diagnostics

  • Chandrashekar et al, SARS-CoV-2 infection protects against rechallenge in rhesus macaques, Science, published online 20 May 2020. Access here.
  • Ni et al, Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals, Immunity, published online 3 May 2020. Access here.
  • Ziegler et al, [Pre-proof] SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues, Cell, published online 29 April 2020 . Access here.
  • Rockx et al, Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model, Science, published online 17 April 2020. Access here.
  • He et al, Temporal dynamics in viral shedding and transmissibility of COVID-19, Nature Medicine, published online 15 April 2020. Access here.
  • Caly et al, Isolation and rapid sharing of the 2019 novel coronavirus (SARS‐CoV‐2) from the first patient diagnosed with COVID‐19 in Australia, Medical Journal of Australia, published online 13 April 2020. Access here.
  • Caly et al, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antiviral Research, published online 3 April 2020. Access here.
  • Walls et al, Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein, Cell, published online 9 March 2020. Access here.
  • Wu et al, Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China, Cell Host & Microbe, published 7 Feb 2020. Access here.
  • Corman et al, Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR, Eurosurveillance, published online Jan 23 2020. Access here.
  • Zhou et al, Discovery of a novel coronavirus associated with the recent pneumonia outbreak in 2 humans and its potential bat origin, bioRxiv, posted online Jan 23 2020. Access here.
  • Killerby et al, Human coronavirus circulation in the United States 2014–2017, Journal of Clinical Virology, 101: 52–56, 2018. Access here.

Vaccines and treatments

  • World Health Organization, A global framework to ensure equitable and fair distribution of COVID-19 products, briefing document published online 18 June 2020. Access here.
  • Zhu et al, Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial, Lancet, published online 22 May 2020. Access here.
  • Pinto et al, Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody, Nature, published online 18 May 2020. Access here.
  • Bojkova et al, Proteomics of SARS-CoV-2-infected host cells reveals therapy targets, Nature, published online 14 May 2020. Access here.
  • Rosenberg et al, Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York State, JAMA, published online 11 May 2020. Access here.
  • Wang et al, Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial, Lancet, pulished online 29 April 2020. Access here.
  • Duan et al, Effectiveness of convalescent plasma therapy in severe COVID-19 patients, PNAS, published online 6 April 2020. Access here.
  • Eyal et al, Human challenge studies to accelerate coronavirus vaccine licensure, The Journal of Infectious Diseases, published online 31 March 2020. Access here.

Preparedness, ethics and other COVID-related research

  • Tangcharoensathien et al, Framework for managing the COVID-19 infodemic: Methods and results of an online, crowdsourced WHO technical consultation, Journal of Medical Internet Research, published online 26 June 2020. Access here.
  • Block et al, Social network-based distancing strategies to flatten the COVID-19 curve in a post-lockdown world, Nature Human Behaviour, published online 4 June 2020. Access here.
  • Dawson et al, Key ethical concepts and their application to COVID-19 research, Public Health Ethics, published online 15 May 2020. Access here. DOI link – not yet active
  • Bartozsco et al, Medical masks vs N95 respirators for preventing COVID‐19 in health care workers a systematic review and meta‐analysis of randomized trials, Influenza and Other Respiratory Viruses, published online 4 April 2020. Access here.
  • Brett-Major et al, Advanced preparation makes research in emergencies and isolation care possible: The case of coronavirus disease, The American Society of Tropical Medicine and Hygiene, published online 30 March 2020. Access here.

Publisher platforms with free papers relevant to the outbreak

Links

Global links

Australian links